Relationship between serum BNP level and atrial fibrillation after coronary artery bypass grafting

SHENG Kai; ZHAO Qi-ming; GAO Bing-ren

doi:10.3969/j.issn.1672-5301.2018.05.020

Abstract：Objective To explore the relationship between serum B-type natriuretic peptide (BNP) and atrial fibrillation after coronary artery bypass grafting.Methods A total of 98 patients underwent coronary artery bypass grafting in our hospital from March 2016 to September 2017 were enrolled in this study,which were divided into atrial fibrillation group (n=37) and sinus rhythm group (n=61) according to whether the patients were atrial fibrillation.The clinical records of patients were collected such as demographic data,disease history,csrdiac function examination,laboratory tests.The relationship between serum BNP and atrial fibrillation was analyzed by the multivariate logistic regression.Results The age,LVEF at 24 h after operation of atrial fibrillation group were more than those of sinus rhythm group,and the serum BNP,hs-CRP levels at 24 h after operation were higher than those of sinus rhythm group,the difference was statistically significant (P＜0.05).Multivariate logistic regression analysis showed that age,LVEF and BNP at 24 h after operative,hs-CRP at 24 h after operative were independent risk factors for atrial fibrillation after coronary artery bypass grafting,with OR of 1.868,1.285,1.784,1.436,the difference was statistically significant (P＜0.05).The area under the ROC curve of serum BNP at 24 h for predicting atrial fibrillation after coronary artery bypass grafting was 0.855(95％CI 0.794-0.915),the best critical value of serum BNP was 107.28 pg/ml,the sensitivity,specificity was 76.35％,82.11％ respectively,and the accuracy of 75.29％.Conclusion Serum BNP is an independent risk factor of atrial fibrillation after coronary bypass grafting,and timely detection with 24 h after operation can be used as an important index to predict atrial fibrillation.