Relationship of blood pressure circadian rhythm with serum albumin and bilirubin

doi:10.3969/j.issn.1672-5301.2018.05.017

Abstract：Objective To investigate the relationship of BP circadian rhythm with serum albumin and bilirubin in these people.Methods All patients who admitted into six departments of Taixing People's Hospital from 2012 to 2015,were included in this study.However,some of them had been excluded if they composited with certain serious diseases,such as acute myocardial infarction,aortic dissection,end-staged of liver,renal,or heart diseases,and so on.All of them underwent 24 hours ambulatory blood pressure monitoring (ABPM) as soon as they were admitted.According whether those systolic blood pressure(SBP) decreased by 10％ or more during the nighttime,those patients were divided into two groups respectively,the dippers and the non-dippers.Besides ABMP,the serum hepatic enzyme,serum albumin and bilirubin were measured and recorded before treatment,and the complications were diagnosed before discharged.Results Up to 1113 patients were enrolled in this study.783 of them were dippers,while 330 were non-dippers.Dippers were older than non-dippers [(62.7±14.5)years vs.(68.7± 13.8)years].And patients in dippers have more coronary heart disease(145 cases vs.97 cases),stroke (226 cases vs.119 cases),diabetes mellitus(142 cases vs.87 cases),chronic renal insufficiency(30 cases vs.24 cases) than those in non-dippers.Dipper patients had higher levels of serum total protein,albumin,prealbumin and ratio of albumin/globulin compared to nor-dippers [(68.3±6.2)g/L vs.(67.4±6.5)g/L,(42.6±4.1)g/L vs.(41.5±4.4)g/L,(243.6±65.1)g/L vs.(229.4±69.2)g/L,and (1.71±0.35)g/L vs.(1.65±0.35)g/L,P＜0.05 respectively].Also ratio of direct bilirubin/total bilirubin in dippers was statistically lower compared to those in nondippers(0.308±0.06 vs.0.321±0.070,P=0.006).With multivariate logistic regression analysis,several factors,including serum albumin and bilirubin were found to independently associate with the circadian rhythm.Conclusion Serum albumin and bilirubin are correlate with the circadian rhythm independently.