Correlation between electrocardiogram QRS complex duration and brain natriuretic peptide in patients with different clinical phenotypes of chronic heart failure

SONG Cui; ZHENG Gang

doi:10.3969/j.issn.1672-5301.2018.05.013

Abstract：Objective To analyze the correlation between electrocardiogram QRS complex duration and brain natriuretic peptide (BNP) in patients with different clinical phenotypes of chronic heart failure (CHF).Methods CHF patients(n=134) were chosen continuously from Feb.2016 to Jun.2017 as CHF group,and other patients without CHF (n=60) were chosen at the same time as control group.CHF group was subgrouped into reduced left ventricular ejection fraction heart failure group(REF,LVEF＜45％,n=60) and preserved left ventricular ejection fraction heart failure group (PEF,LVEF ≥45,n=74) according to left ventricular ejection fraction (LVEF).The QRS complex duration and the level of BNP were detected in all groups.The changes of LVEF were detected by using color Doppler echocardiogram.The difference in QRS complex duration and BNP were analyzed between CHF group and control group and among all subgroups.The correlation between QRS complex duration and BNP and LVEF was studied.Results The QRS complex duration and BNP were significantly increased in patients in CHF than that in control group [(118.76±19.90)ms vs.(82.65±6.16)ms,(587.73±642.30)pg/ml vs.(52.99±12.43)pg/ml,P＜0.05].The QRS complex duration and BNP were significantly increased in patients in REF group than that in PEF group [(136.43±10.86)ms vs.(102.62±10.07)ms,(1071.44±625.68)pg/ml vs.(145.49±149.45)pg/ml,P＜0.05].The QRS complex duration was correlated positively with plasma levels of BNP (r=0.669,P=0.000) and was correlated negatively with LVEF (r=-0.176,P=0.000).Conclusion The QRS complex duration is longer and the level of BNP is higher in CHF patients,and different types of heart failure patients are also different.The QRS complex duration and the level of BNP can be used to help the diagnosis of heart failure types and cardiac function.