The expression of serum miR-423-5p in patients with chronic heart failure and its clinical significance

doi:10.3969/j.issn.1672-5301.2018.05.012

Abstract：Objective To explore the expression of serum microRNA-423-5 (miR-423-5p) in patients with chronic heart failure and its clinical significance.Methods A total of 89 patients with chronic heart failure in our hospital from July 2015 to Marh 2017 as case group were enrolled,at the same time,a total of 35 healthy volunteers as control group were randomly selected.The serum miR-423-5p level of two groups was tested by the real-time quantitative PCR (RT-PCR).Results The serum miR-423-5p level of case group was (0.97±0.32),which was higher than that of control group (0.41±0.28),the difference was statistically significant (t=9.072,P＜0.001).The serum NT-proBNP,LVEDD level in patients with high expression of miR-423-5p were higher than those in patients with low expression of miR-423-5p,and the LVEF level was lower than that in patients with low expression of miR-423-5p,and the classification of cardiac function also was higher than that in patients with low expression of miR-423-5p,the difference was statistically significant (P＜0.05).The sensitivity of miR-423-5p in the diagnosis of chronic heart failure was 89.92％,the specificity was 93.34％,and the AUC of ROC curve was 0.919 (95％CI 0.862-0.975).Conclusion The serum miR-423-5p in patients with chronic heart failure abnormally express,which is closely related to heart function.Early detection can be used as an important bio-marker for assessing the severity of heart failure and diagnosing chronic heart failure.