Effects of early application of recombinant human brain natriuretic peptide on myocardial viability and cardiac function after anterior PCI

doi:10.3969/j.issn.1672-5301.2018.05.007

Abstract：Objective To investigate the effect of early application of recombinant human brain natriuretic peptide on myocardial viability and cardiac function in patients with anterior myocardial infarction (AMI) after emergency PCI.Methods A total of 100 patients were randomly divided into observation group (48 cases) and control group (52 cases).The control group received conventional coronary heart disease treatment;observation group in the conventional treatment of coronary heart disease based on the treatment of recombinant human brain natriuretic peptide.The levels of myocardial viability,cardiac function,BNP,CK-MB,cTnI and the incidence of cardiac adverse events were observed in both groups.Results The improvement rate of segmental improvement in the observation group(62.21％) was higher than that in the control group(46.11％),the difference was statistically significant (P＜0.05).After 1 month of treatment,LVESV,LVEDV,E/A were significantly decreased in both groups,and the observation group[(27.48± 1.35)ml/m2,(54.32±5.27)ml/m2,(0.76±0.03)] was significantly lower than that in the control group[(35.37±1.39)ml/m2,(67.49±6.25)ml/m2,(0.89±0.04)].Two groups of patients with LVEF,CI significantly increased,and the observation group [(59.54±3.01)％,(2.37±0.03)L/m2] was significantly higher than that in the control group[(52.07±3.44)％,(2.05±0.04)L/m2],the difference was statistically significant(P＜0.05).The levels of BNP,CK-MB and cTnI in the observation group were lower than those in the control group,the difference was statistically significant (P＜0.05).The incidence of adverse cardiac events in the observation group was lower than that in the control group for 6 months,the difference was statistically significant (P＜0.05).Conclusion Early application of recombinant human brain natriuretic peptide can improve the myocardial viability of patients with anterior wall AMI after emergency PCI,improve cardiac function and improve the incidence of cardiac adverse events,and have high clinical reference value.