Correlation among homocysteine,brain natriuretic peptide(BNP)and risk stratification of chronic heart
SONG Cui
ZHENG Gang
Abstract：Objective To analyze the changes of levels of homocysteine(Hcy)and brain natriuretic pep-tide(BNP),and correlation among them and risk stratification of chronic heart failure(CHF). Methods CHF pa-tients(n=79)were chosen continuously from Feb. 2016 to Feb. 2017 as CHF group,and other patients without CHF(n=60)were chosen at the same time as control group. CHF group was divided again into Ⅱ-grade subgroup (n=35),Ⅲ-grade subgroup(n=22)and Ⅳ-grade subgroup(n=22)according to NYHA grading method. The lev-els of Hcy and BNP were detected in all groups. The changes of left ventricular ejection fraction(LVEF)were de-tected by using color Doppler echocardiogram. The difference in Hcy level was analyzed between CHF group and control group and among all subgroups. The correlation between Hcy and BNP was studied. Results The levels of Hcy was significantly higher in CHF group than those in control group[(23.15 ±8.26)μmol/L vs(14.79 ± 5.85)μmol/L,P<0.05],and the levels of BNP was also higher in CHF group than those in control group [(485.13±102.43)pg/ml vs.(52.99±12.43)pg/ml,P<0.05]. As the increase of NYHA grade,the levels of Hcy and BNP increased significantly(P<0.05). Hcy was correlated positively to BNP(r=0.22,P=0.048). Conclusion The changes of serum Hcy level can reflect the changes of CHF to some extent.
Keywords：Chronic heart failureHomocysteineBrain natriuretic peptide
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 337-339 )