Effect of Ivabradine on cardiac function and heart rate variability of ischemic cardiomyopathy patients

doi:10.3969/j.issn.1672-5301.2017.11.018

Abstract：Objective To investigate the effect of Ivabradine on cardiac function and heart rate variability (HRV) of ischemic cardiomyopathy (ICM) patients on the basic of conventional therapy.Methods A total of 85 patients diagnosed with ICM were enrolled and divided into conventional therapy group(receiving conventional antiatherosclerosis therapy and placebo,n=42) and Ivabradine group(receiving conventional anti-atherosclerosis therapy and Ivabradine,n=43).Left ventricular ejection fraction (LVEF),NT-proBNP,SDNN,SDANN,RMSSD were recorded and analyzed.Results The levels of LVEF[(31.84±6.08)％ vs (28.12±5.33)％,P＜0.05;(37.73±7.60)％ vs (28.57±5.15)％,P＜0.05] and NT-proBNP [(2181.25±103.94)ng/L vs (2372.61±125.87)ng/L,P＜0.05;1673.43±l14.70)ng/L vs (2401.04±136.19)ng/L,P＜0.05] were significantly improved after 8 weeks of treatment in both groups.The levels of LVEF [(37.73±7.60)％ vs (31.84±6.08)％,P＜0.05] and NT-proBNP [(1673.43 ± 114.70)ng/L vs (2181.25 ± 103.94)ng/L,P＜0.05] were significantly improved in Ivabradine group,compared to conventional therapy group after 8 weeks of treatment (P＜0.05).There was no statistical significance achieved of SDNN,SDANN and RMSSD in conventional therapy group before and after 8 weeks of treatment (P＞0.05).The levels of SDNN(92.89±17.42 vs 64.09±12.03,P＜0.05),SDANN (85.33±15.08 vs 55.49±12.63,P＜0.05) and RMSSD (31.47±7.33 vs 21.35±4.50,P＜0.05) of Ivabradine group were significantly increased after 8 weeks of treatment.And levels of SDNN,SDANN and RMSSD of Ivabradine group were significantly increased compared to those of conventional therapy group after 8 weeks of treatment (P＜0.05).Condusion Ivabradine has more pronounced effect for improving cardiac function and HRV,and it is worthy of clinical promotion.