Investigation of the association between left ventricular concentric hypertrophy and carotid arterial stiffness for patients with hypertension
GAO Jie
YU Ming-yue
NIU Hui-min
Abstract：Objective To investigate the association between left ventricular concentric hypertrophy and carotid arterial stiffness for patients with hypertension.Methods A retrospective study involved 303 patients with hypertension,and 90 age-matched normal controls.The subjects were examined by echocardiography and carotid ultrasound with a high-resolution echo-tracking system.Based on the left ventricular mass index(LVMI) and relative wall thickness (RWT),the patients with hypertension were divided into four patterns of LVH and geometry:normal geometry(N,n=86),concentric remodeling(CR,n=72),concentric hypertrophy CH(n=93) and eccentric hypertrophy(EH,n=52).Intima-media thickness(IMT) and the parameters of arterial stiffness were also assessed using the β stiffness index(β),Young elastic modulus(Ep),arterial compliance(AC),one-point pulse wave velocity(PWVβ) and the wave reflection augmentation index(AI).Results Univariate analysis showed that the following variables were significant in determining CH:ββ＞8.4,Ep＞ 136 kPa,PWVβ＞7.1 m/s,AI＞21.9％,systolic BP＞151 mm Hg,PP＞54 mm Hg,IMT＞0.56 mm and the presence of diabetes.However,by multivariate analysis only AI(OR=3.64,P=0.004),PWVββ＞7.1 m/s(OR=2.82,P=0.013),systolic BP(OR=3.11,P=0.036) and the presence of diabetes(OR=3.73,P=0.007) were associated independently with the occurrence of CH.Conclusion Concentric hypertrophy in hypertension is strongly associated with carotid arterial stiffness and wave reflection parameters,independently of the influence of systolic blood pressure and diabetes.
Keywords：HypertensionLeft ventricular concentric hypertrophyArterial stiffness
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1006-1011 )