Effect of Meglumine Adenosine Cyclophosphate injection on serum hs-CRP and NT-proBNP in patients with acute myocardial infarction
ZHANG Chao-feng
GENG Peng-bo
LI Fen-xia
Abstract：Objective To investigate the clinical value of Meglumine Adenosine Cyclophosphate Injection in the treatment of AMI patients and the influence of hs-CRP and NT-proBNP.Methods 90 patients with AMI in our hospital from March 2015 to May 2016 were randomly divided into study group and control group (n=45),two groups of patients were given thrombolytic therapy + conventional treatment,the study group was treated with Meglumine Adenosine Cyclophosphate Injection at the same time,compared the treatment effect of the two groups of patients.Results The research group of ST segment was more than 50％,the recanalization rate was 86.67％,84.44％,were higher than the control group 66.67％,64.44％,the difference was statistically significant(P＜0.05).After treatment,the study group CI (2.87 ±0.23),cardiac output (5.11 ±0.49)ml,stroke output (66.0±5.1)L/min,and LVEF(62.3±4.9)％,were higher than the control group CI(2.50±0.26),cardiac output(4.72±0.45)ml,stroke output(60.5±3.8)L/min,LVEF(57.5±5.6)％,the difference was statistically significant(P＜0.05).The serum hsCRP of the study group was(5.73±2.20)mg/L,NT-proBNP(251.48±74.02)ng/L,TNF-α(12.61±5.40)μg/L,and sICAM-1 (89.52±27.45)ng/L,were lower than the control group,serum hs-CRP(8.40±2.77)mg/L,NT-proBNP (311.33±81.15)ng/L,TNF-α (16.43±4.08)μg/L,sICAM-1 (110.05±30.62)ng/L,the difference was statistically significant(P＜0.05).Conclusion Meglumine Adenosine Cyclophosphate Injection in the treatment of patients with AMI can help the recovery of cardiac function,reduce the level of inflammatory response,and has a positive effect on the treatment of AMI patients.
Keywords：Cyclic adenosine phosphateAcute myocardial infarctionHigh sensitive C reactive proteinAmino terminal B type natriuretic peptide
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 942-945 )