Meta-analysis of coronary artery bypass grafting combined bone marrow stem cells transplantation treat the left ventricular function in patients with ischemic heart disease
Abstract：Objective To assess the therapeutic effects of BMCs transplantation with CABG in LVEF of ischemic heart disease.Methods Randomized controlled trials of BMSC in combination with coronary artery bypass grafting(CABG) or for LVEF of IHD were identified by searching Pubmed,Embase,CNKI and WanFang Data from their inception to Jan 2017.Screening literature,extracting date and assessing the risk biase of including study was independently accomplished by two researcheres.Then revimen 5.3 software was used to perform metaanalysis.Results 11 RCTs involving 441 patients were included.Meta-analysis revealed that BMSC plus CABG group has no statistical significance in LVEFchange compare to the CABG group(MD=3.27,95％CI-0.39-6.93,P=0.08).However the analysis of different stem cell type showed CD34+ and unselected stem cell group has more efficiently in increasing LVEFchange compare to the control group [CD34+(MD=8.77,95％CI 5.08-12.45,P＜0.01),unselected stem cell (MD=4.28,95％CI 2.38-6.18,P＜0.01)].Nevertheless,left ventricular ejection fraction in CD133+ group was significantly lower (MD=-4.56,95％CI-6.18--2.93,P＜0.01).The analysis for subgroup whether preoperative LVEF＞35％ and whether followed-up period over 6 months was no statistical significance.Conclusion Coronary artery bypass grafting combined bone marrow stem cells transplantation treatment have beneficial effect on the left ventricular function in patients with ischemic heart disease.
Keywords：Coronary artery bypass graftingBone marrow stem cellLeft ventricular function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 932-937 )