A retrospective clinical data analysis of 282 patients with obstructive sleep apnea hypopnea syndrome with hypertension
YANG Bo
CAI Qing-qing
GONG Hai-bin
Abstract：Objective To explore the influencing factors of vascular structure and function,metabolism and average heart rate in patients with hypertension at night with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 360 patients were hospitalized at the cardiovascular medicine of Xuzhou Central Hospital,according to the apnea hypopnea index (AHI) of the patient,the subjects were divided into four groups,which were hypertensive group (AHI＜5 times/h),hypertension group with mild OSAHS (AHI 5-＜15 times/h),moderate OSAHS (AHI 16-＜30 times/h) and severe OSAHS (AHI＞30 times/h).Those groups of clinical data were collected,which including age,waist circumference,blood lipid,fasting blood glucose,fasting insulin,hy persensitive C-reactive protein,carotid-femoral pulse wave velocity,carotid intima-media thickness and polysomnography (PSG).One-way ANOVA and nonparametric tests were used to verify they increased OSAHS or not,multiple linear regression were used to analysis the relationship between heart rate and OSAHS during sleep at night.Results The age,body mass index,waist to hip ratio,waist height ratio,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,high sensitivity C-reactive protein,insulin resistance index,the carotid artery-femoral artery pulse wave velocity,carotid intima-media thickness,the AHI,mean blood oxygen saturation,minimum oxygen saturation,average heart rate in full time,awake,sleep,nonrapid eye movement (NREM),shallow sleep of severe OSAHS combined with hypertension were higher than hypertension group.After correcting the confounding factors by Multiple linear regression analysis,the average heart rate in full time,awake,sleep,NREM,shallow sleep were positively correlated with AHI (β=0.344,P=0.000,β=0.490,P=0.000,β=0.300,P=0.001,β=0.306,P=0.001,β=0.293,P=0.001),and negatively correlated with age (β=-0.312,P=0.000,β=-0.345,P=0.000,β=-0.328,P=0.000,β=-0.331,P=0.000,β=-0.331,P=0.000).Conclusion Severe OSAHS increases the degree of metabolic disorders and vascular remodeling.The average heart rate in full time,awake,sleep,NREM and shallow sleep increases with OSAHS exacerbations,and slows down with age.
Keywords：Obstructive sleep apnea hypopnea syndromeHypertensionMetabolic disordersVascular remodelingHeart rate
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 893-898 )