Association of inflammation-associated gene polymorphism with Warfarin therapy after cardiac valve replacement

CHEN Chong; HE Yong

doi:10.3969/j.issn.1672-5301.2017.09.017

Abstract：Objective To elucidate the relationship between polymorphism of inflammatory gene IL-17 and Warfarin therapy after heart valve replacement.Methods A total of 96 patients were enrolled in this study,and 78 patients who underwent heart valve replacement without warfarin were included in the study.Genomic sequencing.Ninety-six patients who underwent cardiac valve replacement were treated with warfarin as the observation group,and 78 patients who were not treated with warfarin were included as control group.Gene sequencing method was used to determine the content of single nucleoside The polymorphisms of IL-17 and IL-17 were analyzed by using logistic regression analysis.Results The genotype distribution of IL-17 genotype in two groups was different.Logistic regression analysis showed that rs763780 (OR =2.998,95％CI 1.176-7.639,P=0.023) and rs2275913 (OR=2.936,95％CI 1.198-7.246,P=0.019) were the risk factors for postoperative complications of heart valve replacement.Patients with rs763780 genotype had an increased risk of serious complications after cardiac valve replacement.While those with rs2275913 genotype had a 28％ greater risk of serious complications after heart valve replacement (37.34±10.90) months in the patients with high expression of rs2275913 genotype IL-17 and (54.23±12.43)months in the patients with low expression(P＜0.05).There were significant differences between the two groups in the survival and survival time The expression of IL-17 rs2275913 genotype had a certain correlation with the prognosis.Conclusion Gallele of IL-17 is a risk factor for postoperative complications of heart valve replacement.The rs2275913 genotype is associated with heart valve replacement and prognosis,and may be a risk factor for heart valve replacement.