The changes and roles of neuronal nitric oxide synthase in the plasma of patients with chronic heart failure

doi:10.3969/j.issn.1672-5301.2017.09.005

Abstract：Objective To investigate the changes and roles of nNOS in the plasma of patients with chronic heart failure (CHF).Methods 234 consecutive patients with decomposition CHF who were admitted to Yanbian University Hospital from November 2015 to April 2016 were enrolled.According to the left ventricular ejection fraction(LVEF) values,the patients were divided into 3 groups:group A(EF:20％-29％),group B(EF:30％-49％),group C (EF:≥ 50％).In addition,nNOS concentration was compared between the quinquagenarian group and the elderly group.Results (1)The nNOS concentration of plasma in three groups were statistically significant [(87.7±6.6)U/L vs (178.0± 11.5)U/L vs (142.6±8.8)U/L,P＜0.05],among them,plasma nNOS levels in group A were significantly lower than those in group B[(87.7±6.6)U/L vs (178.0±11.5)U/L,P＜0.01];plasma nNOS levels in group C were lower than those in group B[(178.0±11.5)U/L vs (142.6±8.8)U/L,P＜0.05];plasma nNOS levels in group A were lower than those in group C[(87.7±6.6)U/L vs (142.6±8.8)U/L,P＜0.05].(2)There were significant difference in E peak among the three groups[(0.7±0.05)m/s vs (0.9±0.03)m/s vs (0.8±0.03)m/s,P＜0.05],among them,the value of E peak in group A was lower than that in group B[(0.7±0.05)m/s vs (0.9±0.03)m/s,P＜0.05];the value of E peak in group C was lower than that in group B[(0.8±0.03)m/s vs (0.9±0.03)m/s,P＜0.05];the value of E peak in group A was lower than that in group C [(0.7±0.05)m/s vs (0.8 ±0.03)m/s,P＜0.05].(3)Comparison the nNOS concentration of plasma with between the quinquagenarian group and the elderly group.There was no significant difference (P＞0.05).(4)The nNOS concentration of plasma was positively correlated with ACEI,ARB,digoxin and β-blocker.Conclusion The increase of nNOS in patients with heart failure is to protect the cardiac function through the regulation of E peak.