Influence of platelet aggregation inhibition after withdrawal of antiplatelet therapy among coronary artery disease patients before CABG surgery
Abstract：Objective To evaluate the time course of platelet aggregation inhibition after discontinuing antiplatelet therapy among coronary artery disease patients prior to the CABG surgery.Methods 24 coronary artery disease(CAD) patients scheduled for elective CABG who have taken Aspirin(100 mg) and Clopidogrel(75 mg)daily for at least 7 days.Platelet aggregations were measured by light transmission aggregometry triggered with 1 mmol/L arachidonic acid(PL-AA) and 5 μmol/L adenosine diphosphate(PL-ADP) on days 1,2,3,4,5,6,7 and 9 after the last dose of the study drugs.Results AA-induced platelet aggregation was maximally suppressed on day 1 after completion of drug treatment (5.4±1.6)％.Platelet function began to recover on day 3 and returned to normal by day 4 (76.6±4.0)％.ADP-induced platelet aggregation was maximally inhibited on day 1 after completion of drug treatment(29.5±12.1)％ and returned to normal by day 7(69.7±3.5)％.Conclusion Platelet aggregations triggered with arachidonic acid returned to normal by day 4 among coronary artery disease patients prior to the CABG surgery,and platelet aggregations triggered with adenosine diphosphate returned to normal levels by day 7 among coronary artery disease patients prior to the CABG surgery.
Keywords：Coronary artery bypass graftPlatelet aggregationsArachidonic acidAdenosine diphosphate
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 715-719 )