Correlation analysis between blood glucose fluctuation and coronary artery lesions on the patients with acute myocardial infarction

doi:10.3969/j.issn.1672-5301.2017.06.018

Abstract：Objective To explore the correlation between blood glucose fluctuation and coronary artery lesions on the patients with acute myocardial infarction.Methods 156 patients who hospitalized because of acute ST segment elevation myocardial infarction(STEMI) in Department of Cardiology,Daxing Hospital of Capital Medical University were selected from Feb 2012 to Dec 2015.The patients were monitored glucose using Medtronic continuous glucose monitoring system(CGMS,Minimed) for 72 hours.All patients underwent coronary angiography and coronary lesions SYNTAX score was calculated.The patients were divided into A group(STEMI with DM) and B group (STEMI without DM) based on whether accompanied DM or not.The patients also were divided into MAGE＞3.9 mmol/L group and MAGE ≤3.9 mmol/L group according to the MAGE was normal or not.Correlation between blood glucose excursion and coronary artery lesions were analyzed.Results The mean blood glucose (MBG) and standard deviation of blood glucose(SDBG) of group A was significantly higher than group B [(9.7± 0.7)mmol/L vs (5.5±2.1)mmol/L,(2.5±1.2)mmol/L vs (1.2±0.8)mmol/L,P＜0.01].The mean amplitude of glycemic excursions(MAGE) of group A was significantly higher than that of group B[(3.8±l.2)mmol/L vs (2.6±1.3)mmol/L,P＜0.01].The.SYNTAX score of group A was significantly higher than group B (17.3±4.7 vs 13.5±3.3,P＜0.01).The SYNTAX score of the patients with MAGE＞3.9 mmol/L was also higher than that of the patients with MAGE≤3.9 mmol/L (18.9±3.1 vs 14.7±4.5,P＜0.01).The SYNTAX score was positively correlated with MAGE,MBG and HBA1c (r=0.854,0.372,0.468,P＜0.01).Conclusion There is significant positive correlation between glucose excursion and severity of coronary artery lesions in patients with acute myocardial infarction.