Analysis on the expression of platelet derived growth factor (PDGF) in patients with coronary atherosclerosis and its clinical monitoring significance

ZHAO Li-yan; LUAN Li-ping; SHAO Feng

doi:10.3969/j.issn.1672-5301.2017.06.012

Abstract：Objective To explore the expression of platelet derived growth factor(PDGF) in patients with coronary atherosclerosis and its clinical monitoring significance.Methods 190 patients with coronary angiography and IVUS examination were selected as study subjects,they were divided into stable plaque group(56 cases),vulnerable plaque group (44 cases),mixed plaque group(50 cases) and coronary angiography no abnormal group (40cases) according to coronary angiography and IVUS examination results.The expression level of serum PDGF-mR-NA was detected by RT-PCR method,the total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL-C),low density lipoprotein(LDL-C),blood uric acid (UA),blood urea nitrogen (BUN),carrying lipoprotein A (apoaA),set the apolipoprotein B (apoaB) were detected at the same time.The Gensini integral system was used for quantitative evaluation of each coronary artery according to the results of each patient's arterial angiography.The correlation between PDGF-mRNA expression level and the above factors was analyzed.Results (1)There were significant differences in the level of PDGF-mRNA expression in each group,and the value of the Vulnerable plaque group ＞ the mixed plaque group ＞ the stable plaque group ＞ the no abnormal group(P＜0.05).(2)The TC,TG,UA levels were compared among the groups,in which the values of vulnerable plaque group was the highest,the other was mixed plaque group,stable plaque group,no abnormal group,the difference was statistically significant.The Gensini score of the vulnerable plaque group was highest,and followed by the mixed plaque group,the value of stable plaque group was lowest (P＜0.05).(3)Pearson bivariate correlation analysis showed that:PDGF-mRNA expression levels were positively correlated with Gensini score(r=0.34,P=0.003),BMI (r=0.15,P=0.032),TG (r=0.21,P=0.011),TC (r=0.17,P=0.015);PDGF-mRNA expression levels were negatively correlated with HDL-C (r=-0.25,P=0.013),and were not related with age(r=0.05,P＞0.05),gender(r=0.09,P＞0.05),BUN (r=0.07,P＞0.05),UA (r=0.03,P＞0.05),apoaA (r=0.06,P＞0.05) and apoaB (r=0.10,P＞0.05).(4)Logistic regression analysis showed that the higher of Gensini score (β=0.31),BMI(β=0.23),TG(β=0.13),TC (β=0.10),the greater of PDGF-mRNA value.The expression level of HDL-C (β=-0.17) was negatively correlated with the level of PDGF-mRNA.Conclusion Platelet-derived growth factor (PDGF) was the independent risk factor of coronary atherosclerosis,whose expression level was closely related to the severity of coronary artery disease.Close monitoring of patients with PDGF-mRNA expression levels can objectively assess the extent of coronary lesions.