The influence of hypercapnia on early postoperative cognitive function in bronchoscope intervention

doi:10.3969/j.issn.1672-5301.2017.06.007

Abstract：Objective The principal objective of this dissertation is to understand the influence of hypercapnia on postoperative cognitive function in bronchoscope intervention.Methods A total of 102 patients were studied during general anesthesia with rigid bronchoscope intervention.The patients were divided into two groups according to the partial pressure of carbon dioxide(PaCO2) in arterial blood gas analysis(ABG),the control group with PaCO2≤45 mm Hg and the hypercapnia group with PaCO2＞45 mm Hg.At the time points of one day before and seven days after the surgeries,the cognitive function of the patients was measured by Mini-Mental state examination (MMSE) and Montreal Cognitive Assessment(MoCA).Results The performance of the hypercapnia group in MMSE moderately improved after surgery (P＜0.05),however,there existed no difference between the marks of the hypercapnia group and the control group after surgery(P＞0.05).The MoCA evaluation of the hypercapnia group improved after surgery(P＜0.05) and the mark was even higher than the mark of the control group after surgery(P＜ 0.05).In terms of the measurement of the cognitive test of each section,the hypercapnia group indicated higher visual spatial ability and execution score(P＜0.05) and higher delayed recall ability score(P＜0.05) after surgery than before.Conclusion In bronchoscope intervention,mild hypercapnia might ameliorate the early cognitive function of the patients after surgery,especially in visual spatial ability and execution and delayed recall ability.