The relationship between serum omentin-1 levels and microalbuminuria among prehypertensive patients with overweight

doi:10.3969/j.issn.1672-5301.2017.05.012

Abstract：Objective To observe serum omentin-1 levels and microalbuminuria among prehypertensive patients with overweight,and assess the relationship between serum omentin-1 levels and microalbuminria.Methods A total 208 subjects with normal blood pressure and prehypertension were recruited from the physical examination center of our hospital,from April 2015 to Jun 2015.They were divided to three groups:the normal group (n=66),the prehypertension group(n=70),and the prehypertension with overweight(n=72) according to blood pressure and body mass index (BMI),fasting plasma glucose,dyslipidemia,plasma uric acid,creatinine and urea nitrogen were measured.Serum omentin-1 was measured and by ELLSA method and microalbuminuria by immunoturbidimetry.Results Serum omentin-1 levels were significantly lower in the prehypertension group [(41.02±9.02)ng/ml] and with overweight group [(35.91±10.83)ng/ml] than the normal control group [(54.96± 8.94)ng/ml](P＜0.05),in the prehypertension with overweight group was further lower (P＜0.05).Of three groups examined,microalbuminuria was highest in the prehypertension with overweight group [(26.19±24.97)mg/L,P＜ 0.05],and it was higher in the prehypertension group [(17.66±9.50)mg/L] than in the normal control group [(5.08±0.22)mg/L] (P＜0.05).Pearson correlation analyses showed that serum omention-1 was negatively related with BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),FBG,TC,MAU,while positively related with HDL-C in the total prehypertension.MAU was positively related with age,BMI,SBP,fasting plasma glucose,LDL-C,while negatively associated with omentin-1.The multivariable logistic regression analysis demonstrated MAU was independently associated with SBP,while omentin-1 was not into regression equation in every group.Conclusion Microalbuminuria existed in patients with prehypertension,and more obviously in patients with overweight.The result reflected that omentin-1 may be involved in the procession of MAU in the prehypertension group.