The relationship between HP infection and serum lipid metabolism in patients with coronary heart disease

LI Zhe; WANG Ya-ping; MENG Hang

doi:10.3969/j.issn.1672-5301.2017.04.012

Abstract：Objective To investigate the relationship between Helicobacter pylori (HP) infection and serum lipid metabolism in patients with coronary heart disease.Methods From May 2013 to May 2016,selected 150 patients with coronary heart disease (CHD group),while 100 cases of healthy persons as control group,HP infection was detected by 14C urea breath test,according to the results,patients with coronary heart disease were divided into non infection (n=76),mild infection (n=53) and severe infection (n=21),according to SYNTAX score,patients were divided into low risk,medium risk and high risk patients,measured each subjects serum lipid levels.Results The infection rates of HP in CHD group and control group were 49.33％ and 41.00％,there was no significant difference(P＞0.05).TC,TG and LDL-C in CHD group were(5.50±0.81)mmol/L,(2.31± 0.52) mmol/L and (3.70±0.83)mmol/L,significantly higher than that in control group,while HDL-C was (0.93± 0.27) mmol/L,significantly lower than that in control group,the difference was statistically significant (P＜0.05).Severe infection patients TC and TG were (6.11 ± 1.09) mmol/L and (2.53±0.31) mmol/L,significantly higher than that of non infection and mild infection patients (P＜0.05).Severe infection and mild infection patients HDL-C were (0.82±0.36)mmol/L and (0.99±0.42)mmol/L,significantly lower than that of non infection patients (P＜0.05),and LDL-C were (3.83±1.10)mmol/L and (3.31±1.03)mmol/L,significantly higher than those in non infection patients(P＜0.05).Different proportions of coronary lesions in patients with different HP infection difference was no statistical significance (P＞0.05).Conclusion HP infection is not associated with coronary heart disease,but HP infection may promote the development of coronary heart disease by affecting the body lipid metabolism.