The correlation study of Galectin-3 and chronic heart failure

doi:10.3969/j.issn.1672-5301.2017.04.011

Abstract：Objective To study the clinical value of plasma galectin-3 levels in patients with chronic heart failure(CHF).Methods A total of 120 patients with CHF(New York Heart Association functional class Ⅱ-Ⅳ) were enrolled as experiment group,and 40 patients were collected as control group.Plasma Gal-3 and NT-proBNP levels were measured by Elise.Echocardiography was performed to determine left ventricular end-diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF).The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of Gal-3 or NT-proBNP in CHF.Results The level of Gal-3 in heart failure group was significantly higher than that in control group[19.5(10.21-22.59)ng/ml vs 5.75(4.66-13.89)ng/ml,P＜0.05],and its level in heart failure group was increasing with the increase of cardiac function grade.The level of the plasma galectin-3 was positively correlated with NT-proBNP(r=0.766,P＜0.01) and left ventricular end diastolic diameter(r=0.496,P＜0.05),and negatively correlated with LVEF(r=-0.634,P＜0.01).Conclusion The level of the plasma galectin-3 had certain relevance with CHF,and it was related to the changes of left ventricular function and structure,which indicated that plasma Gal-3 may have been involved in the process of left ventricular remodeling in CHF.Gal-3 has highly diagnostic value to the chronic heart failure.