A study between inflammatory mediators and acute coronary sysdrom
Abstract：Objective To observe the role of venous blood interleukin-17 (IL-17),high-sensitivity Creactive protein (hs-CRP) in acute myocardial infarction,unstable angina,and coronary heart disease stable angina expressing the difference to discuss the role of IL-17,hs-CRP in the pathological basis research of ACS patients.Methods In total,from 2015 July to December,96 patients with symptoms of coronary heart disease in Shanxi Cardiovascular Hospital were recruited.All patients were divided into four groups:AMI group (n=29),UAP group(n=27),SAP group(n=20),HC group(n=20).All patients were blood at once in hospital or the after morning.The serum levels of IL-17 and hs-CRP were detected by ELISA method.Meanwhile collect all patients' clinical data.Results At admission,Serum IL-17,hs-CRP levels in AMI group patients were significant increased compared with other groups (all P＜0.05).The serum level of hs-CRP was increased in UAP group compared with SAP group,HC group (all P＜0.05).In the relation analyze,the relation between IL-17 and hs-CRP showed a positive correlation (r=0.365,P＜0.01).In the regression analysis,the factors enabling the higher serum level of IL-17 conclude WBC count.The factors enabling the higher serum level of hs-CRP conclude the history of hypertension,the level of serum LDL-C,the WBC count (P＜0.01).Conclusion The inflammation factors level such as IL-17,hs-CRP were obvious different in ACS patients,which may suggest the inflammation factors level were higher,inflammation may participate in the occurrence and the progress of ACS.The relation between IL-17 and hs-CRP shows a preferable correlation.
Keywords：Interleukin-17High-sensitivity C-reactive proteinAcute coronary syndrome
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 150-153 )