Cost-Utility Analysis of Repetitive Transcranial Magnetic Stimulation Combined with Donepezil in the Treatment of Alzheimer's Disease
Xie Linbo
Zhang Fan
Xiao Feiyi
Wu Xingqi
Jiang Litian
Li Peiyao
Ji Gongjun
Wang Kai
Zhu Jiming
Abstract：Objective:To evaluate the cost-utility of repetitive Transcranial Magnetic Stimulation(rTMS)combining with Denepezil for Alzheimer's Disease(AD)treatment and provide scientific evidence for clinical decision-making.Methods:Based on clinical trial data,a cost-utility analysis was conducted collecting direct medical costs,direct non-medical costs,and indirect costs of rTMS treatment Combined with Donepezil.Health utility values were assessed using Mini-Mental State Examination(MMSE)conversion formula.The Incremental Cost-Utility Ratio(ICUR)was calculated with sensitivity analysis performed.Results:Total cost of rTMS combined treatment for AD was 404 421.5 yuan with incremental health utility of 0.47.The ICUR was below three times Gross Domestic Product(GDP)threshold,indicating cost-effectiveness compared to traditional therapy.Sensitivity analysis showed transition probability of mild AD is the key parameter influencing this ratio.However,the results remain robust even when this parameter fluctuates within a reasonable range.Conclusion:The combination of rTMS and donepezil demonstrates economic feasibility in treating Alzheimer's disease and significantly improves patient health utility scores.Its clinical implementation is recommended.
Keywords：Alzheimer's DiseaseRepetitive Transcranial Magnetic Stimulation Combined with Donepezilhealth economics evaluationcost-utility analysis
Publication Date：2026-02-05
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：5( 61-65 )