Cost-utility Analysis of Tuberculosis Preventive Treatment Strategies for Latent Tuberculosis-Infected Patients in Xinjiang
Wang Xiaomin
Wang Senlu
Wang Jun'an
Jiayina·Lazibieke
Wen Baofeng
Abulikemu·Aili
Zhang Yaying
Guliziba·Kuerbanjiang
Cao Mingqin
Abstract：Objective:To conduct a cost-utility analysis of Tuberculosis Preventive Treatment(TPT)strategies for Latent Tuberculosis Infection(LTBI)individuals,providing a scientific basis for the implementation of TPT strategies and fund allocation.Methods:Based on a simulated population of 100 000 LTBI individuals,a decision tree-Markov Model was constructed to compare the cost-utility of six TPT strategies over 20 years.Results:Compared with no treatment,3HP-SAT,3HP-DOT,3HR-SAT,3HR-DOT and Vaccae could prevent 91.08％,94.15％,83.49％,87.18％and 53.13％of ATB cases,respectively,and avoid 3.55％,3.70％,3.30％,3.43％,and 2.06％of LTBI individuals from dying of ATB.Except for Vaccae,other schemes could reduce costs and improve QALYs,being absolutely dominant strategies,while Vaccae was a relatively dominant strategy.3HP under DOT was more cost-utility than that under SAT.Sensitivity analysis showed that the utility value of curing ATB was the only parameter affecting the ICUR result,and the model result was stable and reliable.When the WTP threshold was greater than 41 608.54 yuan/QALY,3HP-DOT was better than 3HP-SAT;otherwise,3HP-SAT was the optimal strategy.Conclusion:TPT for LTBI individuals has high cost-utility value.Clarifying the advantages of short-course therapy helps promote the implementation of TPT strategies and contributes to achieving the goal of"ending tuberculosis".
Keywords：latent tuberculosis infectionpreventive treatmentcost-utility analysisdecision tree-Markov ModelXinjiang
Publication Date：2025-09-05
Online Publishing Date：2025-10-14(First online date of this platform, not the publication date of the document)
Pages：6( 90-95 )