Advances in cancer-associated fibroblast research and their impact on targeted therapy for glioma
ZHAO Dachuan
ZHANG Jiazheng
ZHANG Wei
Abstract：The tumor microenvironment(TME)is a key factor in tumor progression,and various components within it play specific roles.As one of the main components,cancer-associated fibroblast(CAF)have gradually become one of the focuses of tumor-related research in recent years.This article summarizes the current research status of CAF in glioma and other tumors,including the origin and heterogeneity of CAF,their interaction with tumor cells(with a particular focus on their inhibitory effect on the immune microenvironment),as well as the research progress of CAF-targeted therapy.Although research on CAF in glioma is relatively limited,it can be inferred from the current research that CAF-targeted therapy has potential research and application value in glioma,and it is worthwhile to explore more CAF targets in the future.
Keywords：gliomacancer-associated fibroblasttumor microenvironmenttargeted therapy
Publication Date：2026-01-20
Online Publishing Date：2026-02-07(First online date of this platform, not the publication date of the document)
Pages：8( 56-63 )