Blood Free DNA Fragmentome: New Advances in Non-invasive Diagnosis of Brain Tumors
Abstract：Approximately 19,000 people die from primary brain tumors in the United States each year, but there is currently no effective method for early screening during the asymptomatic stage [1]. Brain tumors often present with non-specific neurological symptoms such as headache and nausea, which can lead to missed diagnosis at initial consultation. There is a significant delay between the onset of symptoms and diagnosis. Global imaging screening strategies are not yet unified: the UK guidelines recommend head CT scans for patients with neurological symptoms, while most countries lack a standardized approach, relying mainly on the subjective judgment of clinicians. This symptom-based imaging screening strategy has a low positive predictive value, leading to a large number of unnecessary examinations and many patients failing to receive timely imaging evaluation. Most brain tumor patients are diagnosed at an advanced stage [2].
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Publication Date：2025-12-20
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：1( 757 )