Molecular Boundary Detection Technology Promotes Glioma Surgery from 'Anatomical Resection' to 'Molecular Radical Cure'
Abstract：IDH wild-type glioblastoma (GBM) is the most aggressive primary brain tumor, and its treatment remains a major challenge in the field of neuro-oncology. Even with maximal safe resection combined with adjuvant radiotherapy and chemotherapy, the median survival time of patients is still about 15 months, and tumor recurrence is almost inevitable [1-2]. The current dilemma is largely due to the difficulty in accurately assessing tumor remnants beyond the imaging boundaries. To improve surgical accuracy, various intraoperative techniques have been developed and applied, including intraoperative MRI and ultrasound, multimodal neuro-navigation, neurophysiological monitoring, fluorescence guidance (such as 5-aminolevulinic acid) [3], Raman spectroscopy, and cell-level microscopes [4-5]. These technologies have advanced surgery, but each has its own limitations. In recent years, the concept of 'molecular boundaries' has gradually emerged, providing a new direction for GBM surgery. A prospective study by MASSAAD et al. [6] showed that expanded resection based on molecular boundaries can bring survival benefits to patients with IDH wild-type GBM.
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Publication Date：2025-11-20
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：1( 692 )