Clinicopathological observation of the central nervous system lymphomatoid granulomatosis
WANG Xiaolu
WANG Shengchao
WANG Xiaoyang
YE Yali
ZONG Jiawen
YUE Li
CHEN Lin
WANG Zuocai
Abstract：Objective To enhance the clinicopathological understanding of central nervous system lymphomatoid granulomatosis(CNS-LyG).Methods Clinical data of 4 patients with CNS-LyG were analyzed retrospectively,including clinical manifestations,pathological morphology,immunohistochemistry,and in situ hybridization,supplemented by a literature review.Results The clinical manifestations of CNS-LyG varied depending on the lesion location and extent of damage,with no characteristic serological findings.CT or MRI revealed non-characteristic patchy or strip-like enhancement at the lesion site.Pathologically,it was characterized by the presence of varying numbers of mildly immature lymphocyte-like cells proliferating around capillaries in brain tissue,forming sheet-like distributions.Immunohistochemical markers were often polyclonal.The Epstein-Barr virus-encoded RNA(EBER)test results were negative.Treatment primarily involved surgery,supplemented by immunotherapy and/or radiotherapy/chemotherapy.Prognosis was associated with the location,size,and grade of the lesion.Conclusions CNS-LyG is rare,and its diagnosis requires a comprehensive analysis combining clinical manifestations,pathological morphology,immunohistochemistry,and in-situ hybridization.When atypical cells show single immunohistochemical marker expression,it suggests the possibility of malignant lesions,necessitating further immunohistochemical and molecular testing.The prognosis of CNS-LyG is related to its pathological grading.
Keywords：central nervous system lymphomatoid granulomatosisclinicopathologyimmunohistochemistry
Publication Date：2025-11-20
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：5( 674-678 )