Analysis of the factors influencing transient ischemic attack after endovascular interventional therapy for ruptured intracranial aneurysms
LIU Xinhua
DENG Jianzhong
LV Gaopeng
Abstract：Objective To explore the factors influencing transient ischemic attack(TIA)after endovascular interventional therapy for ruptured intracranial aneurysms.Methods The clinical data of 224 patients with ruptured intracranial aneurysms,all of whom received endovascular interventional therapy,were analyzed retrospectively.They were divided into a TIA group(n=71)and a non-TIA group(n=153)based on whether TIA occurred within 14 days after treatment.Clinical data of the patients,as well as their serum levels of tumour necrosis factor-alpha(TNF-α),interleukin(IL)-6,and IL-8,were collected.Multivariate logistic regression analysis was used to investigate the influencing factors for TIA after endovascular interventional therapy for ruptured intracranial aneurysms.Results TIA occurred in 71 patients after treatment,with an incidence rate of 31.70%(71/224).There were statistically significant differences between the TIA group and the non-TIA group in terms of age,hypertension,smoking,alcohol abuse,and Hunt-Hess grade(all P<0.05).The levels of TNF-α,IL-6,and IL-8 before treatment in the TIA group were significantly higher than those in the non-TIA group(all P<0.05).Multivariate logistic regression analysis showed that age(OR=1.731,95%CI:1.149-2.607),hypertension(OR=1.556,95%CI:1.049-2.307),smoking(OR=1.982,95%CI:1.069-3.675),alcohol abuse(OR=2.352,95%CI:1.175-4.707),Hunt-Hess gradeⅢ-Ⅳ(OR=2.327,95%CI:1.120-4.834),and TNF-α(OR=3.154,95%CI:1.188-8.371)were risk factors for TIA after endovascular interventional therapy for ruptured intracranial aneurysms(all P<0.05).Conclusions Age,hypertension,smoking,alcohol abuse,Hunt-Hess grade,and TNF-α level can all influence the occurrence of TIA after endovascular interventional therapy for ruptured intracranial aneurysms.Reasonable clinical interventions should be implemented,and individuals should quit smoking and drinking to reduce the occurrence of TIA.
Keywords：intracranial aneurysmrupturedtransient ischemic attackendovascular intervention
Publication Date：2025-10-20
Online Publishing Date：2025-12-01(First online date of this platform, not the publication date of the document)
Pages：4( 589-592 )