Application of ctDNA Liquid Biopsy Based on Individualized Amplification Breakpoints in Monitoring High-Grade Gliomas
Abstract：Gliomas are common primary intracranial tumors, among which high-grade gliomas are characterized by short survival periods, high disability rates, and heavy medical burdens [1]. Although surgery combined with radiotherapy and chemotherapy has become the standard treatment, many patients with high-grade gliomas experience recurrence shortly after treatment ends. Due to the imaging changes caused by radiotherapy that resemble tumor progression, it is difficult for clinicians to distinguish pseudo-progression, radiation necrosis, and true tumor progression through imaging alone [2]. Early identification of radiation necrosis and tumor progression is crucial for promptly adjusting treatment plans to improve patient symptoms. Therefore, seeking an early and accurate method to assess tumor progression is essential.
Machine-generated Keywords：
Publication Date：2025-08-20
Online Publishing Date：2025-08-29(First online date of this platform, not the publication date of the document)
Pages：1( 503 )