The rise of personalized brain-computer interfaces:precision neuromodulation in functional neurosurgery
Wang Yuxin
Liu Jiayu
Su Shichao
Gao Zhao
Wang Bingxian
Dang Yuanyuan
Xu Aoxi
Zhao Hulin
Zhang Jianning
Abstract：Brain-computer interface(BCI)serves as a bridge connecting the brain to external devices,demonstrating significant advancements in functional neurosurgery.Currently,BCI technology is extensively utilized for motor function reconstruction,neuromodulation,and the treatment of neurological and psychiatric disorders.Nevertheless,existing systems continue to face substantial challenges in decoding accuracy,long-term stability,and adaptability.The introduction of personalized brain-computer interface(PBCI),through the integration of multimodal data and artificial intelligence technologies,has markedly enhanced the precision and adaptability of BCI systems.This review comprehensively summarizes the fundamental concepts,key technologies,and application potential of PBCI in functional neurosurgery.Firstly,it elaborates on the theoretical foundations and structural components of PBCI from the perspective of personalized medicine,emphasizing the critical role of integrating brain imaging,genomic,and behavioral data in optimizing signal decoding and treatment strategies.Secondly,it focuses on technological innovations of PBCI in the integration of BCI with deep brain stimulation(BCI-DBS),multimodal imaging analysis,and artificial intelligence fusion.This section clarifies the principles and methodologies for achieving personalized neuromodulation,and discuss its practical applications in treating such conditions as Parkinson's disease,epilepsy,and obsessive-compulsive disorder(OCD).Finally,the review sums up clinical application cases and prospects of PBCI in managing Parkinson's disease and epilepsy,outlines current technical challenges in PBCI development,and envisions future directions in closed-loop regulation,neural network analysis,and personalized medicine.By advancing personalized brain-computer interfaces,functional neurosurgery holds promise for delivering more precise and efficient neuromodulation therapies,thereby offering new therapeutic horizons for patients with neurological disorders.
Keywords：brain-computer interfacedeep brain stimulationfunctional neurosurgerymultimodal dataneuromodulation
Publication Date：2025-08-20
Online Publishing Date：2025-08-29(First online date of this platform, not the publication date of the document)
Pages：7( 489-495 )