Efficacy analysis of YL-1 intracranial hematoma puncture combined with bioenzymatic liquefaction in treating hypertensive intracerebral hemorrhage
Zhou Chunpeng
Liu Guanghui
Wang Xiangxiang
Hong Xuanke
Zhang Gangzhong
Abstract：Objective To investigate the clinical efficacy of YL-1 intracranial hematoma puncture combined with bioenzymatic liquefaction(hereinafter referred to as minimally invasive puncture)in treating hypertensive intracerebral hemorrhage(HICH).Methods A prospective,single-blind,controlled design was employed,involving 300 HICH patients who were randomly divided into a craniotomy drainage group(n=150,undergoing craniotomy hematoma drainage)and a minimally invasive puncture group(n=150,undergoing minimally invasive puncture)according to a random number table.The hematoma evacuation rate,surgery-related indicators,serum oxidative stress indicators,including 8-hydroxy-2'-deoxyguanosine(8-OHdG),myeloperoxidase(MPO),and malondialdehyde(MDA)before surgery and on postoperative days 3 and 7,neurological function scores[assessed using the National Institutes of Health Stroke Scale(NIHSS)],prognosis[evaluated using the Glasgow Outcome Scale(GOS)],and complication rates were compared between the two groups.Results The minimally invasive puncture group exhibited a higher hematoma evacuation rate and superior intraoperative blood loss,surgical duration,incision length,and hospital stay compared to the craniotomy drainage group(all P<0.05).On postoperative days 3 and 7,serum levels of 8-OHdG,MPO,and MDA were lower in the minimally invasive puncture group than in the craniotomy drainage group(all P<0.05).At 3 months postoperatively,the minimally invasive puncture group showed better GOS and NIHSS scores compared to the craniotomy drainage group(both P<0.05).The overall complication rate was lower in the minimally invasive puncture group than in the craniotomy drainage group(P<0.05).Conclusions Minimally invasive puncture for HICH patients optimizes the surgical process,enhances hematoma evacuation,reduces oxidative stress and neurological damage,lowers the risk of complications,and improves patient prognosis.
Keywords：intracranial hemorrhagehypertensivepuncturebiological enzymehematoma drainageneurological injury
Publication Date：2025-07-20
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：5( 418-422 )