Nomogram prediction model for delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage
Feng Cuiling
Tian Jinying
Wang Shufeng
Fang Dandong
Abstract：Objective To establish a Nomogram prediction model for delayed cerebral ischemia(DCI)in patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods Clinical data of 210 patients with aSAH were analyzed retrospectively,who were divided into the DCI group(n=50)and the non-DCI group(n=160)based on the occurrence of DCI.Molecular biological indicators and clinical characteristics were compared between the two groups.Lasso regression and Logistic regression analysis was applied to identify the influencing factors for DCI in aSAH patients.A nomogram prediction model for DCI in aSAH patients was then established based on these influencing factors.Results The incidence of DCI within 30 days postoperatively in aSAH patients was 23.81%.Hyponatremia,hypoproteinemia,Hunt-Hess grade,Fisher grade,World Federation of Neurosurgery(WFNS)grade,as well as serum levels of interleukin-6(IL-6),C-reactive protein(CRP),soluble lectin-like oxidized low density lipoprotein receptor-1(sLOX-1),hypoxia inducible factor 1α(HIF-1α),endothelin-1(ET-1),and insulin-like growth factor-1(IGF-1)at admission were all identified as influencing factors for DCI in aSAH patients(all P<0.05).A nomogram prediction model for DCI in aSAH patients was established based on these influencing factors.The model exhibited a high predictive efficacy with an area under the curve(AUC)of 0.908 and demonstrated good clinical utility,showing a high concordance rate between predicted and actual occurrences of DCI in aSAH patients.Conclusions Hyponatremia,hypoproteinemia,Hunt-Hess grade,Fisher grade,WFNS grade,as well as serum levels of IL-6,CRP,sLOX-1,HIF-1α,ET-1,and IGF-1 at admission are all influencing factors for DCI in aSAH patients.The established nomogram prediction model provides a reliable clinical basis for early identification of high-risk patients with DCI in clinical practice.
Keywords：subarachnoid hemorrhagedelayed cerebral ischemianomogramprediction
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 298-304 )