Clinicopathological analysis of spinal Rosai-Dorfman disease
Yue Li
Han Leng
Wang Shengchao
Wang Xiaoyang
Chen Lin
Lai Xuwen
Zong Jiawen
Wang Xiaolu
Su Longjun
Wang Zhuocai
Abstract：Objective To investigate the clinicopathological characteristics,diagnosis,and differential diagnosis of spinal Rosai-Dorfman disease(RDD).Methods The clinicopathological data of 3 patients with spinal RDD were analyzed retrospectively,including histological characteristics,immunohistochemistry,and molecular pathology,along with a review of relevant literature.The patients comprised 1 male and 2 females.Results Laboratory examinations revealed increased levels of monocytes,lymphocytes,reticulocytes,and platelet hematocrit,with decreased levels of albumin,total protein,and cystatin C.Imaging studies(CT and MRI)demonstrated space-occupying lesions.Microscopic examination revealed nodular aggregates of histiocytes mixed with lymphocytes and plasma cells were observed on a background of fibrosis or collagenization.Typical"emperipolesis"was observed in histiocytes,characterized by the presence of engulfed lymphocytes,plasma cells,and erythrocytes within the cytoplasm.Immunophenotypically,histiocytes were positive for S-100 and CD68,and negative for CD1a.Lymphoma gene rearrangement testing was negative.Conclusions Spinal RDD is a rare benign histiocytic proliferative disorder,lacking characteristic clinical manifestations,serological,or imaging findings.Diagnosis relies on pathological morphology and immunohistochemistry.
Keywords：histiocytosissinusspinal cordpathlolgyclinical
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 285-289 )