The Paradigm Shift in Glioblastoma Research: Neuronal-Tumor Network
Abstract：1 The Paradigm Shift in Neuronal-Tumor Network Research
Traditional research has considered that the impact of glioblastoma (glioblastoma multiforme, GBM) on the brain network mainly results from its physical destruction of brain tissue, such as tumor mass effect causing disruption of white matter fiber tracts or functional connections, leading to changes in functional networks. Recent studies have found that the interaction between GBM and the brain network is far from a unidirectional 'destruction-compensation' model, but rather exhibits a dynamic bidirectional regulatory characteristic [1]. Particularly noteworthy is that tumor cells can actively integrate into neural circuits, forming functional coupling with neurons through synaptic transmission or neuroelectric activity-dependent signaling [2]. The interaction between tumor cells and neural circuits, especially the communication between synaptic neurons and tumors, has become a key factor in tumor progression and invasion [3].
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Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：1( 189 )