The predictive role of D-dimer in the prognosis of intracranial aneurysms
Gao Dandan
Hou Bin
Gao Yang
Li Chuangzhong
Abstract：Objective To analyze serum indicators for predicting the prognosis of aneurysmal subarachnoid hemorrhage(aSAH).Methods Clinical data of 150 patients with intracranial aneurysms were analyzed retrospectively.These patients were categorized based on Hunt-Hess grading:50 cases of grade 0(unruptured),50 cases of mild aSAH(gradesⅠ-Ⅱ),and 50 cases of severe aSAH(grades Ⅲ-V).All the patients underwent interventional embolization.Postoperative follow-up was conducted using the modified Rankin scale(mRS)to assess prognosis,and the patients with mRS of 0-2 were divided into the good prognosis group and 3-5 divided into the poor prognosis group.Serum D-dimer levels were compared between the two groups,and the sensitivity and specificity of D-dimer were analyzed.Results There were 127 cases in the good prognosis group and 23 in the poor prognosis group.There was a statistically significant difference in D-dimer and length of hospital stay between the two groups(both P＜0.05).The cut-off value of D-dimer for patients with intracranial aneurysm with different prognosis was 1.99,AUC was 0.94,(95%CI:0.90-0.98,P＜0.0001),the sensitivity was 77.8%and specificity 70.3%.Conclusions There are many factors affecting the prognosis of intracranial aneurysm,and clinical intervention should be taken in advance according to the specific characteristics of patients.D-dimer has a certain predictive value for the poor prognosis of patients with intracranial aneurysm.
Keywords：intracranial aneurysmsubarachnoid hemorrhageD-dimerrisk factorspredictive value
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 74-77 )