A mendelian randomized study of the causal association between serum lipidome and glioblastoma
Sun Yingwei
Wang Geyu
Dai Xuejian
Yang Ruoyu
Ning Yisheng
Feng Sizhe
Abstract：Objective To investigate the potential causal relationship between serum lipidome and glioblastoma(GBM)using a two-sample bidirectional Mendelian randomization(MR).Methods This study utilized publicly available genome-wide association study(GWAS)summary statistics for serum lipidome and GBM.Single nucleotide polymorphisms(SNPs)associated with serum lipidome were employed as instrumental variables(IV).The causal effects were primarily assessed using the inverse-variance weighted(IVW)method,supplemented by Bayesian weighted Mendelian randomization(BWMR)to further elucidate the causal relationships.Sensitivity analyses,including leave-one-out analysis,heterogeneity tests,and horizontal pleiotropy assessments,were conducted to evaluate the stability and reliability of the results.Results After MR analysis combined with BWMR analysis and correction for false discovery rate(FDR),11 serum lipids were found to be associated with GBM risk(P<0.05).Specifically,phosphatidylethanolamine(18:0_0:0),phosphatidylcholine(16:0_18:2),phosphatidylcholine(16:0_20:2),phosphatidylcholine(18:1_18:1),phosphatidylcholine(18:1_18:2),phosphatidylcholine(18:1_20:2),phosphatidylcholine(18:2_18:2),and phosphatidylcholine(O-16:0_18:1)were identified as risk factors for GBM.Conversely,phosphatidylinositol(18:0_20:4),sphingomyelin(d38:2),and triacylglycerol(56:6)as protective factors against GBM.Sensitivity analyses did not reveal significant heterogeneity or horizontal pleiotropy.Conclusions Specific serum lipids may have a causal association with the risk of GBM.
Keywords：glioblastomalipidomicspolymorphismsingle nucleotideMendelian randomization analysis
Publication Date：2025-01-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 52-58 )