Effects of activation of non-classical NF-κB signaling pathway by vesicle amine transport protein 1 on prognosis and treatment of glioma
Shan Xia
Sun Zhiyan
Wang Kuanyu
Bao Zhaoshi
Yang Pei
Abstract：Objective To explore the potential mechanism of vesicle amine transport protein 1(VAT1)in promoting the malignant phenotype of brain glioma.Methods All samples were downloaded from the Chinese Glioma Genome Atlas(CGGA)database and The Cancer Genome Atlas(TCGA)database.Combined with the expression of VAT1,clinical information and transcriptome data were analyzed to evaluate the effect of VAT1 expression on the prognosis of patients.Bioinformatics analysis was used to explore the possibly activated signal pathway with VAT1 up-regulation.Results A total of 226 patients with whole-grade glioma in CGGA database and 651 patients in TCGA database were included in this study.Survival analysis showed that the overall survival(OS)was significantly shortened in patients with high expression of VAT1(P<0.001).Multivariate Cox regression analysis showed that VAT1 expression was an independent prognostic factor in glioma patients(HR=2.427,95%CI:1.451-4.061,P=0.001).Transcriptome data analysis showed that the gene function positively related to VAT1 expression was involved in inflammation and immune response,angiogenesis and hypoxia response.The up-regulation of VAT1 expression may activate the non-classical NF-κB signaling pathway.Analysis of the impact on treatment suggests that the patient with high expression of VAT1 was resistant to radiotherapy.Conclusions The high expression of VAT1 in glioma patients significantly affects prognosis and leads to treatment resistance.Inhibition of VAT1 combined with other anti-tumor therapies may enhance anti-tumor effects.
Keywords：gliomavesicle amine transport protein 1treatment resistanceprognosis
Publication Date：2025-01-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 38-44 )