Analysis on correlation of tau protein,glial fibrillary acidic protein,and anti-β2 glycoprotein 1 antibody levels with prognosis in patients with hypertensive intracerebral hemorrhage
Li Xinru
Wang Liuxiang
Abstract：Objective To analyze the correlation between tau protein,glial fibrillary acidic protein(GFAP),and anti-β2 glycoprotein 1 antibody(aβ2-GP1)levels and the prognosis of patients with hypertensive intracerebral hemorrhage(HICH).Methods Seventy patients with HICH were included in observation group,and another 70 healthy individuals undergoing physical examinations during the same period were included in the control group.The levels of tau protein,GFAP,and aβ2-GP1 were compared between the two groups.The levels of tau protein,GFAP,aβ2-GP1,and the National Institutes of Health Stroke Scale(NIHSS)scores were compared between HICH patients with different prognoses,and their correlations were analyzed.Receiver operating characteristic(ROC)curve analysis was used to evaluate the clinical value of relevant indicators in predicting poor prognosis in HICH patients.Results Compared with the control group,the levels of tau protein,GFAP,and aβ2-GP1 were significantly higher in the observation group(P<0.05).Patients with poor prognosis had higher levels of tau protein,GFAP,aβ2-GP1,and NIHSS scores(P<0.05).All relevant indicators were positively correlated with NIHSS scores(all P<0.05).The optimal cut-off values for predicting poor prognosis in HICH patients were tau protein≥258.15 ng/L,GFAP≥16.15 ng/L,and aβ2-GP1≥18.35 RU/mL,with areas under the curve(AUCs)of 0.908(95%CI:0.828-0.988,P<0.05),0.871(95%CI:0.781-0.961,P<0.05),and 0.839(95%CI:0.728-0.949,P<0.05),respectively.The sensitivity was 77.27%,77.27%,and 72.73%,and the specificity was 97.92%,85.42%,and 89.58%,respectively.Conclusions Patients with HICH exhibit elevated levels of tau protein,GFAP,and aβ2-GP1,indicating more severe neurological damage.Patients with poor prognosis have even higher levels of these indicators.Monitoring the levels of these biomarkers can be used to assess the poor prognosis of HICH patients.
Keywords：cerebral hemorrhagehypertensivetau proteinglial fibrillary acidic proteinanti-β2-glycoprotein 1 antibody
Publication Date：2024-08-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 458-461 )