Therapeutic effect of vitamin B6 combined with mouse nerve growth factor on children with refractory epilepsy

Wang Ruili; Liu Xiaoyan

doi:10.11850/j.issn.1009-122X.2024.07.007

Abstract：Objective To investigate the efficacy of vitamin B6 combined with mouse nerve growth factor in the treatment of children with refractory epilepsy(RE).Methods A total of 89 children with RE were randomly divided into observation group(n=43)and control group(n=46)based on their hospitalization numbers.The control group received levetiracetam tablets on the basis of the original antiepileptic drugs,while the observation group was additionally treated with vitamin B6 combined with mouse nerve growth factor.The clinical efficacy,changes in peripheral blood levels of miR-99a-5p,miR-125b-5p,and ubiquitin C-terminal hydrolase-L1(UCH-L1)after treatment,effects on electroencephalographic activity,and improvements in intellectual level and quality of life were compared between the two groups.Results The overall response rate in the observation group was higher than that in the control group,with a statistically significant difference(P<0.05).After treatment,the levels of miR-99a-5p,miR-125b-5p,UCH-L1,and theta wave in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the scores of verbal IQ,performance IQ,and full-scale IQ,as well as the total score of the Quality of Life in Childhood Epilepsy(QOLCE)scale,were significantly higher in the observation group than in the control group,with statistically significant differences(P<0.05).Conclusions The treatment of RE with vitamin B6 combined with mouse nerve growth factor shows good efficacy.It can significantly reduce the levels of miR-99a-5p,miR-125b-5p,and UCH-L1 in peripheral blood,control electroencephalographic activity,and thereby improve the intellectual level and quality of life of children with RE.