Evaluation role of neurodynamic time-varying network analysis in the diagnosis and treatment of epilepsy
Luo Juan
Chen Xin
Yu Sixun
Shu Haifeng
Abstract：Objective To explore the role of time-varying network analysis based on neurodynamics in the preoperative assessment and prognosis prediction for patients with refractory epilepsy(RE).Methods The clinical data of 18 patients with RE were analyzed retrospectively.Synchronized and desynchronized stereotactic electroencephalography(SEEG)data were studied.All the 18 patients with RE underwent radiofrequency thermocoagulation(RF-TC)treatment after preoperative multimodal assessment.Results SEEG synchronization and desynchronization indices showed opposite trends.The results of receiver operating characteristic(ROC)curve and area under the curve(AUC)for synchronization and desynchronization indicated that as the ipsilateral synchrony of the epileptogenic zone increases when transitioning from pre-seizure to seizure state,desynchronization will relatively weaken;as the ipsilateral synchrony of the epileptogenic zone weakens,desynchronization will increase.During the 3-18 months of follow-up,patients with RE who underwent RF-TC showed improved prognosis with increase of desynchronized activity on the ipsilateral side of the epileptogenic zone and decrease of synchronized activity.Conversely,prognosis worsened with increase of synchronized activity on the ipsilateral side of the epileptogenic zone and decrease of desynchronized activity.Conclusions Determination of RF-TC targets based on the changes in synchronization and desynchronization activities in the epileptogenic zone,as derived from the time-varying network analysis method based on neurodynamics,can significantly improve patient prognosis.
Keywords：epilepsyrefractorystereotactic electroencephalographytime-varying network analysissynchronization
Publication Date：2024-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 331-339 )