Persistent spike-and-slow wave activations during sleep in childhood self-limiting focal epilepsy impair the attention network function
Wang Xiaocui
Li Mengning
Wu Lulu
Yang Yang
Ye Xiaofei
Yang Bin
Abstract：Objective To investigate the characteristics of attention network function in children with self-limited focal epilepsies(SeLFE)with EEG combined with persistent spike-and-slow wave activation during sleep.Methods The attention networks test(ANT)was performed to assess the attention network function in the SeLFE group(n=54)and the healthy control group(n=55),and the ANT parameters and the electroencephalogram(EEG)spike and wave index(SWI)during non-rapid eye movement(NREM)sleep period were collected and statistically analyzed.Results The accuracy rate of the ANT was 92.96%±6.93%in the SeLFE group and(98.05%±2.19%)in the healthy control group,showing a statistically significant difference(t=-5.150,P<0.05).The total average response time of the ANT was(987.46±189.45)ms in the SeLFE group and(788.73±181.42)ms in the control group,with the SeLFE group having a longer response time and a statistically significant difference(t=5.594,P<0.05).The execution function network efficiency was 76.00(21.50,110.75)ms in the SeLFE group and 54.00(-4.00,89.00)ms in the control group,with the SeLFE group showing a longer time and a statistically significant difference(t=-2.151,P=0.031).There were no significant differences in alerting network efficiency or orienting network efficiency between the two groups(P>0.05).The accuracy rate of the ANT was 90.89%±7.52%in the high SWI group(NREM period SWI>60%)and 95.04%±5.71%in the low SWI group(SWI≤60%),with the high SWI group showing a lower accuracy rate and a statistically significant difference(t=-2.284,P<0.05).Both multiple linear regression analysis and Kendall tau-b correlation analysis indicated that the SWI affected the total average accuracy rate of the ANT(F=2.664,P=0.021;Kendall tau-b=-0.331,P=0.001),but did not affect the total average response time.Conclusions The children in the SeLFE group have attention network function impairment,and the execution control network damage is the main problem,and SWI affects the total average accuracy of ANT.
Keywords：epilepsyspike-and-wave activation in sleepattention networks test
Publication Date：2024-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 261-266 )