Diagnostic and therapeutic value of neuron-specific enolase,angiotensin Ⅱ,and malondialdehyde in intracranial infections
Wu Jianhong
Wang Jun
Dai Shanshan
Dong Guoli
Abstract：Objective To investigate the diagnostic and therapeutic value of neuron-specific enolase(NSE),angiotensinⅡ(Ang-Ⅱ),and malondialdehyde(MDA)in intracranial infections after craniotomy for cerebral hemorrhage.Methods The clinical data of 95 patients undergoing craniotomy for cerebral hemorrhage were retrospectively analyzed.The patients were divided into infection group(n=35)and non-infection group(n=60)based on whether intracranial infection occurred within one week after surgery.The baseline data,biochemical indicators including white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT),and albumin(ALB),and laboratory indicators(NSE,Ang-Ⅱ,MDA)were compared between the two groups.Logistic multivariate regression analysis was used to analyze the risk factors for intracranial infection after craniotomy for cerebral hemorrhage.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of NSE,Ang-Ⅱ,and MDA in intracranial infections after craniotomy for cerebral hemorrhage.All the patients in the infection group received intrathecal drug therapy,and were divided into infection-controlled group(n=25)and infection-uncontrolled group(n=10)based on clinical signs after 3 days of treatment.The levels of NSE,Ang-Ⅱ,and MDA were measured at 3,7,and 14 d after treatment.Results Compared with the non-infection group,the infection group had a higher incidence of diabetes mellitus and postoperative coagulation dysfunction,and higher levels of PCT,ALB,NSE,Ang-Ⅱ and MDA(P<0.05).Logistic multivariate regression analysis showed that diabetes mellitus(OR=1.812,95% CI:1.505-2.515),postoperative coagulation dysfunction(OR=1.856,95% CI:1.512-2.526),high PCT level(OR=1.850,95% CI:1.519-2.494),high NSE level(OR=1.824,95% CI:1.537-2.638),high Ang-Ⅱ level(OR=1.885,95% CI:1.584-2.649),and high MDA level(OR=1.964,95% CI:1.558-2.715)were independent risk factors for intracranial infection after craniotomy for cerebral hemorrhage.The AUC for the combined diagnosis of intracranial infection after craniotomy for cerebral hemorrhage with NSE,Ang-Ⅱ,and MDA was 0.912(95% CI:0.740-0.948).Dynamic changes in NSE,Ang-Ⅱ,and MDA levels at 14 d after treatment showed that the levels of NSE,Ang-Ⅱ,and MDA in the infection-controlled group were lower than those in the infection-uncontrolled group at 3,7,and 14 d after treatment(P<0.05).Conclusion The combined detection of NSE,Ang-Ⅱ,and MDA can improve the diagnostic value and therapeutic efficacy evaluation for intracranial infection after craniotomy for cerebral hemorrhage.
Keywords：intracranial infectionneuron specific enolaseangiotensin Ⅱmalondialdehyde
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 215-220 )