Microsurgery and prognosis of glioma in the corpus callosum

Cheng Chuandong; Peng Nan; Ji Ying; Cheng Wei; Xia Yanghua; Qian Zhongrun

doi:10.11850/j.issn.1009-122X.2024.03.003

Abstract：Objective To explore the efficacy and prognostic factors of microsurgery for glioma in the corpus callosum.Methods The clinical data of 50 patients with glioma in corpus callosum were retrospectively analyzed,and the tumors were located in the anterior part of the corpus callosum in 42,body in 1 patient,and splenium in 7.All the patients underwent microsurgical resection,and 6 of them received preoperative navigation combined with intraoperative MRI-assisted tumor resection.There were 42 cases of glioblastoma,4 of oligodendroglioma,3 of diffuse astrocytoma,and 1 case of ependymoma.Results According to the Karnofsky performance scale score(KPS score)1 month after operation,the patients were divided into two groups:the better prognosis group(KPS score≥70 points)with 26 cases and the poor prognosis group(KPS score<70 points)with 24.In univariate analysis,there were statistically significant differences in patient survival,lesion involvement of internal capsule,left cortical destruction during surgery,and total tumor resection(all P<0.05).Multivariate logistic regression model analysis showed that the postoperative KPS score was related to the involvement of the internal capsule and the destruction of the left cortex during surgery(all P<0.05).Conclusions For some patients with glioma in the corpus callosum,microsurgical resection of the tumor can improve the postoperative KPS score of the patient,which can benefit the patient.A reasonable surgical plan should be formulated before surgery to avoid left cortical injury,protect the internal capsular return vein and anterior cerebral artery,and avoid excessive opening of the ventricles.In the patients with tumor involvement in the hypothalamus and third ventricle,partial resection of the tumor may be considered to reduce intracranial pressure.