Precise localization of epileptogenic focus via application of depth electrodes for temporal lobe epilepsy
Zhang Wenqian
Wang Jiarui
Zhang Linlin
Zhu Hongjing
Wang Tao
Zhao Quanjun
Abstract：Objective To investigate the clinical value of depth electrodes for accurate localization of epileptogenic focus in temporal lobe epilepsy.Methods The depth electrodes of brain were implanted for 28 patients who were suspected of temporal lobe epilepsy.At most 3 electrodes were implanted as the targets in the medial temporal lobe and trajectories via frontal lobe,lateral temporal lobe and occipital-parietal lobe respectively for the main suspected side and 1-2 electrodes for the other according to the specific circumstance.The maximum of 6 electrodes were applied to the patients who were suspected of bilateral temporal lobe epilepsy.Results The site of epileptogenic focus was confirmed and the corresponding operation was performed in 27 patients,including 19 cases of medial temporal lobe epilepsy,5 of lateral temporal lobe epilepsy,and 3 of extratemporal organic lesions caused by seizures.CT/MRI showed organic lesions occurred in 9 cases,of which 1 was non-epileptogenic lesion.The total seizure-free rate was 62.96%(17/27),in which 5 underwent stereotactic amygdalohippocampal coagulation,3 hippocampal transection,5 anterior temporal lobectomy and 4 structural lesion resection.Conclusions Accurate application of deep brain electrodes can achieve the accurate localization effect of epileptic foci caused by temporal lobe epilepsy,reduce surgical trauma,protect brain tissue function,and also have positioning value for seizures caused by extratemporal organic lesions.
Keywords：epilepsytemporal lobedepth electrode of brainstereotaxic techniqueshippocampal transectionanterior temporal lobectomy
Publication Date：2024-01-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 4-7 )