Analysis of the efficacy of atorvastatin calcium in the treatment of chronic subdural hematoma
Li Shihao
Wang Shaohua
Abstract：Objective To investigate the efficacy of atorvastatin calcium administered at different time points following drilling drainage surgery for chronic subdural hematoma(CSDH).Methods A total of 72 patients with CSDH were divided into a control group(n=32)and a study group(n=40).Patients in the control group began taking atorvastatin calcium tablets one week after surgery(average 12.52±2.53 days)and continued for 8 weeks.Patients in the study group started taking the same dose of atorvastatin calcium within one week after surgery(average 1.42±0.84 days)for the same duration.Hematoma volume,neurological function,and activities of daily living(ADL)were compared between the two groups at 1 and 3 months postoperatively.Results Preoperative hematoma volumes were similar between the control group(73.53±17.64 ml)and the study group(74.10±17.95 ml),with no statistically significant difference(P>0.05).At 1 month postoperatively,hematoma volumes were significantly lower in the study group(22.52±3.96 ml)compared to the control group(29.62±4.20 ml,P<0.001).At 3 months,hematoma volumes continued to be lower in the study group(11.87±2.48 ml)than in the control group(13.09±2.24 ml,P<0.05).Chinese Stroke Scale(CSS)scores were comparable preoperatively between the control group(19.18±4.84)and the study group(18.75±5.32,P>0.05).However,at 1 month postoperatively,CSS scores improved significantly in the study group(9.87±3.26)compared to the control group(13.87±3.43,P<0.001).This trend persisted at 3 months,with the study group scoring lower(5.25±2.72)than the control group(6.65±2.65,P<0.05).Preoperative ADL scores were similar between the two groups(control group:54.06±16.51;study group:56.87±14.74,P>0.05).At 1 month,ADL scores improved significantly in the study group(75.37±11.11)compared to the control group(67.96±11.27,P<0.05).However,at 3 months,the difference in ADL scores between the two groups was not statistically significant(control group:86.25±10.31;study group:90.37±8.27,P>0.05).Conclusions Early administration of atorvastatin calcium tablets after surgery can promote hematoma absorption,neurological recovery,and improve ADL in CSDH patients.
Keywords：subdural hematomachronicatorvastain calciumdrilling drainage
Publication Date：2023-12-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 136-139 )