The correlation between IFABP,TLR4,ITF and the occurrence of gastrointestinal dysfunction in patients with stroke
Xing Jiajia
Bai Mingyi
Abstract：Objective To analyze the correlation of intestinal fatty acid-binding protein(IFABP),Toll-like receptor 4(TLR4),intestinal trefoil factor(ITF)and the occurrence of gastrointestinal dysfunction in patients with stroke.Methods According to the presence or absence of gastrointestinal dysfunction within 7 days of admission,68 patients with stroke were divided into a control group(without gastrointestinal dysfunction,n=41)and an observation group(with gastrointestinal dysfunction,n=27).The National Institutes of Health Stroke Scale(NIHSS)scores and the levels of IFABP,TLR4 and ITF were compared between the two groups.The good prognosis rate of the two groups was counted.Receiver operating characteristic(ROC)curve was used to analyze the value of IFABP,TLR4 and ITF levels in predicting the occurrence of gastrointestinal dysfunction and poor prognosis in patients with stroke.Results Compared with the control group,the NIHSS score and the levels of IFABP,TLR4 and ITF in the observation group were higher(P<0.05).The good prognosis rate of the observation group was lower than that of the control group(55.56%vs.78.05%,P<0.05).The optimal critical values of IFABP,TLR4 and ITF for predicting gastrointestinal dysfunction in stroke patients were IFABP≥367.85μg/L,TLR4≥3.78 ng/ml and ITF≥14.40μg/L,respectively.And the area under the curve was 0.851,0.838 and 0.744(P<0.05),respectively.The sensitivity was 77.78%,70.37%,77.78%,respectively,and the specificity was 92.68%,92.68%,75.61%,respectively.The optimal critical values of IFABP,TLR4 and ITF for predicting poor prognosis of stroke patients were IFABP≥336.10μg/L,TLR4≥3.05ng/ml,ITF≥15.95μg/L,respectively.And the area under the curve was 0.914,0.925,0.930(P<0.05),respectively.The sensitivity was 100.00%,100.00%,76.19%,respectively,and the specificity was 70.21%,65.96%,95.74%,respectively.Conclusions The NIHSS score,IFABP,TLR4 and ITF levels are higher in stroke patients with gastrointestinal dysfunction,and the risk of poor prognosis is higher.Detection of IFABP,TLR4 and ITF levels in stroke patients can predict the risk of gastrointestinal dysfunction and poor prognosis.
Keywords：strokegastrointestinal dysfunctionintestinal fatty acid-binding proteinToll-like receptor 4intestinal trefoil factor
Publication Date：2023-12-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 123-126 )