Value of serum Omentin-1,Trx1 and caveolin-1 in diagnosis and prognosis of hypertensive intra cerebral hemorrhage

Lv Jiatao; Yan Fei; Ma Lili

doi:10.11850/j.issn.1009-122X.2023.12.024

Abstract：Objective To investigate the expression of Omentin-1,thioredoxin 1(Trx1)and caveolin-1 in patients with hypertensive intracerebral hemorrhage(HICH)and their prognostic value.Methods A retrospective analysis was performed on 82 patients with HICH who underwent minimally invasive hematoma removal from February 2020 to May 2023,and they were divided into good prognosis group(n=48)and poor prognosis group(n=34)according to their recovery 30 days after treatment.Serum levels of Omentin-1,Trx1,caveolin-1,Glasgow Coma Scale(GCS)score and Graeb ventricular hemorrhage score were compared between the two groups at admission,and their correlation was analyzed.The predictive value of subjects curve analysis was used to analyze the risk of adverse outcomes of patients with different levels of indicators at admission.Results The serum levels of Omentin-1 in the good prognosis group were higher than those in the poor prognosis group,and the serum levels of Trx1 and caveolin-1 were lower than those in the poor prognosis group(P<0.05).The GCS score of the poor prognosis group was lower than that of the good prognosis group,and the Graeb score was higher than that of the good prognosis group(P<0.05).Serum Trx1 and caveolin-1 levels were negatively correlated with GCS score and positively correlated with Graeb score.The area under the ROC curve(AUC)for each indicator in predicting an adverse prognosis was all greater than 0.6,but the AUC for the combined diagnosis was the largest at 0.857(P<0.05).The risk of having a poor prognosis in patients with high levels of Omentin-1,Trx1 and caveolin-1 at admission for HICH is 2.462,3.440,and 0.242 times higher,respectively,than in patients with low levels.Conclusions Serum Omentin-1 levels were decreased and serum Trx1 and caveolin-1 levels were increased in patients with HICH upon admission.The combined detection of all indicators has high predictive value for poor prognosis,and can be used as an auxiliary indicator for clinical evaluation of prognosis in patients with HICH.