The expression and prognostic significance of MED8 gene in glioma
Liu Yuanyuan
Li Bangan
Chen Guanggui
Wu Yonghui
Zhou Jinxu
Abstract：Objective To investigate the expression and prognostic significance of the MED8 gene in glioma tissues through analysis of the CGGA and TCGA databases.Methods Differential expression of the MED8 gene in gliomas compared to normal tissues was analyzed using the TIMER2.0 online tool for TCGA database and protein expression differences were assessed using the HPA database.Glioma patient samples from the CGGA database,including mRNAseq_693 and mRNAseq_325 sequencing data and clinical information,were analyzed using R software for clinical correlation analysis,prognostic survival analysis,and both univariate and multivariate COX regression analysis.Additionally,Receiver Operating Characteristic(ROC)curves were constructed to assess the prognostic significance of MED8 in the glioma patient cohort.Gene Set Enrichment Analysis(GSEA)was utilized to investigate the role of MED8 in gliomas,complemented by gene co-expression correlation analysis.Results MED8 expression was significantly elevated in glioma tissues compared to normal brain tissue,with higher expression levels associated with poorer prognosis in glioma patients(P<0.001).Furthermore,this study identified MED8 as an independent prognostic marker for predicting glioma patient outcomes.Conclusion The findings support the hypothesis that MED8 may play an oncogenic role in glioma tissues and highlight its potential as a novel biomarker for predicting the prognosis of glioma patients.
Keywords：gliomaMED8 geneprognosisbioinformatics methods
Publication Date：2023-12-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 40-45 )