The application and safety of low-energy X-ray intraoperative radiotherapy in the treatment of malignant glioma
Wang Qiang
Ding Wei
Liu Feng
Ma Chiyuan
Sun Xiangdong
Pan Hao
Abstract：Objective To evaluate the safety and initial adverse effects of intraoperative radiotherapy(IORT)for malignant glioma.Methods Malignant glioma patients received low-energy X-ray intraoperative radiotherapy(LEX-IORT)after conventional craniotomy for tumor resection.Patients'postoperative status and complications were recorded and compared with those of malignant glioma patients who had not receive intraoperative radiotherapy(the conventional surgery group).Results A total of 14 malignant glioma patients,8 males and 6 females,were enrolled in this study.All patients received IORT of 20Gy.The average surgical duration was 262.1±55.6 min in the IORT group and 222.6±53.5 min in the conventional surgery group(P=0.061).The average postoperative hospital stay was 13.9±5.6 days in the IORT group and 10.3±4.7 days in the conventional surgery group(P=0.071).The patients in the IORT group did not have postoperative intracranial infection,hydrocephalus,postoperative seizures,cerebral hemorrhage and incision infection.One patient's incision was dehiscenced during concurrent chemoradiotherapy and no infection occurred.The incision re-healed after replacing the suture and discontinuation the use of Anlotinib,without affecting radiotherapy.All patients of both groups had completed standard radiotherapy with concomitant temozolomide as planned.Conclusion LEX-IORT at a dose of 20Gy is generally safe for patients with malignant glioma without adding additional complications.
Keywords：gliomamalignantintraoperative radiotherapylow-energy X-raysafety
Publication Date：2023-12-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 28-34 )