Application of dentatorubrothalamic tract tractography by diffusion tensor imaging in deep brain stimulation for the treatment of tremor symptoms of Parkinson Disease
Chen Yukun
Wang Xuelian
Abstract：Objective To evaluate the clinical value of the dentatorubrothalamic tract tractography by diffusion tensor imaging (DTI) in deep brain stimulation (DBS) for the treatment of tremor symptoms of Parkinson Disease. Methods The clinical data of 7 patients diagnosed as having idiopathic Parkinson Disease with tremor symptoms were analyzed retrospectively. The dentatorubrothalamic tract was traced by software with preoperative and postoperativeMRI, CT image data. The unilateral electrode was implanted into 2 patients with unilateral tremor symptom, bilateral electrodes in 5 patients with bilateral tremor symptoms. There were 4 contacts in each side of DBS electrode and totally 48 contacts. The 42 contacts were effective, 6 contacts were excluded due to complications. The nearest space distance of 42 effective contacts to dentatorubrothalamic tract was calculated. The correlation between the improvement of tremor and the distance was analyzed. Results Under the same stimulus parameters, the nearest space distance of contact to the dentatorubrothalamic tract was 1.74±1.13 mm in ＞ 50％ improvement of tremor group and 2.76±1.22 mm in≤50％ group, the difference between the two groups was statistically significant (t =2.78, P ＜ 0.05). The nearest space distance of each electrode contact to the dentatorubrothalamic tract was related to the improvement of tremor (R =0.55, P ＜ 0.05). Conclusions DBS of the dentatorubrothalamic tract is in coincidence with the improvement of tremor. In the future, we need further rigorous clinical trials to verify its application value in order to achieve precise target location and individualized treatment.
Keywords：Parkinson Diseasediffusion tensor imagingdentatorubrothalamic tractdeep brain stimulationtremor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 193-196 )